Bob Malcolm will take charge of East Fife for the first time when Forfar visit New Bayview.
Former Rangers, QPR and Motherwell midfielder Malcolm has taken over first-team affairs in the absence of manager Gordon Durie, who is ill, and following the resignation of assistant boss Gordon Chisholm.
Along with fellow coach Brian McNaughton he will pick a side that will not include the injured Scott McBride and the ill Jamie Pollok.
The Fifers are looking for their first home win of the season.
Malcolm said: "I had been helping Gordon Chisholm out so I knew the boys anyway. Training has gone well this week and I am looking forward to pitting my wits against a wily campaigner in Dick Campbell. Hopefully we can grab that first win."
James Craigen will be included in the Forfar squad.
The midfielder has joined the club on loan from Partick Thistle.
Michael Bolochoweckyj is available after a two-game ban and Michael Dunlop has returned from a loan spell at East Stirling.
However, the Station Park side have been hit by injuries with Odmar Faeroe, Jamie Bishop, Keith Gibson, Barry Sellars and Gavin Swankie all ruled out with knocks.
Manager Dick Campbell, whose side are looking to bounce back from their 3-2 defeat at Alloa in their last outing, said: "We do have a number of concerns personnel-wise but I am looking for us to keep hold of second place by winning at East Fife.
"We lost a lot of goals to East Fife last season and I certainly do not want that to happen again."